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Sigma
N-Nitrosohexamethyleneimine
N5154
DOWNLOAD MSDS (PDF)Synonym: Hexahydro-
CAS Number: 932-83-2
Empirical Formula (Hill Notation): C6H12N2O
Molecular Weight: 128.17
EC Number: 213-258-6
MDL number: MFCD00467141
PubChem Substance ID: 24897723
Properties
| Related Categories | Enzyme Inhibitors, Enzyme Inhibitors by Type, Substrate Analogs |
| refractive index | n |
| bp | 233 °C(lit.) |
| density | 1.06 g/mL at 25 °C(lit.) |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Mutagenic and carcinogenic.1 A trace-enrichment HPLC method has been developed for quantitating this compound as an impurity (to ppb levels) in tolazamide2, and potentially other pharmaceutical preparations.
Price and Availability
Safety Information
| Symbol |   GHS07, GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H335-H350 |
| Precautionary statements | P201-P261-P305 + P351 + P338-P308 + P313 |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Hazard Codes | T |
| Risk Statements | 45-22-36/37/38 |
| Safety Statements | 53-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | CM3325000 |
| Flash Point(F) | 210.2 °F |
| Flash Point(C) | 99 °C |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
1. Goodall, C.M., et al., Tumorigenicity of N-nitrosohexamethyleneimine Cancer Res. 28, 1217-1222, (1968)
2. Severin, G., Monitoring a potential carcinogen in pharmaceutical formulations at the low part per billion level. High-performance liquid chromatographic determination of N-nitrosohexamethyleneimine in tolazamide J. Chromatogr. 386, 57-63, (1987)
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